RESUMO
The smooth muscle of thoracic aorta from guinea pig sensitized with egg albumin (EA) produced an anaphylactic contraction when it was exposed to EA. Experiments were performed to evaluate stress effects on the anaphylactic contraction in guinea pig aortic rings. Two types of stressors were used as immunosuppressor stimuli: physical restraint and shaking of the animals. Both stressors diminished the amplitude of the Schultz-Dale contraction in aortic rings from sensitized guinea pig. The shake stress stimulus interrupted several times during each session induced higher immunosuppression in animals in which the active sensitization and the stress sessions began the same day. Severe restraint stress, prior to active immunization, also suppressed significantly the anaphylactic response. The Schulz-Dale reaction in guinea pig aorta seems to be a valuable technique to study the stress effects on the anaphylactic response.
Assuntos
Aorta Torácica/fisiologia , Anafilaxia/imunologia , Anafilaxia/fisiopatologia , Animais , Aorta Torácica/imunologia , Cobaias , Tolerância Imunológica , Imunização , Técnicas In Vitro , Masculino , Músculo Liso Vascular/imunologia , Músculo Liso Vascular/fisiologia , Norepinefrina/farmacologia , Ovalbumina/imunologia , Restrição Física , Estresse Mecânico , Vasoconstrição/imunologia , Vasoconstrição/fisiologiaRESUMO
Extraparotid Warthin's tumors continue to challenge the head and neck surgeon's diagnostic and therapeutic skills. A series of six extraporotid Warthin's tumors are presented to illustrate the need to keep a high index of suspicion for this lesion in the workup of cystic masses involving cervical levels II and III or in the event of a concomitant neck mass and a parotid Warthin's tumor. Discussion of the debate surrounding the embryogenesis and histogenesis of extraparotid Warthin's tumors follows. Clinical guidelines are suggested for the diagnosis, treatment, and follow-up of patients with extraparotid Warthin's tumors.
